Antibodies, which bind to the viral proteins, are detected by an enzyme-mediated color change. Prospective evaluation of an algorithm incorporating HSV-1 serostatus found that 11 of 70 persons with indeterminate HSV-2 ELISAs were Western blot-positive.Ĭlinicians should consider selectively using a higher index value to define Focus ELISA HSV-2 positivity based on either HSV-1 serostatus or clinical circumstances. The strips of paper or 'blots' containing separated fixed proteins from either HSV-1 or HSV-2 are incubated with the patient's serum. Selectively raising the ELISA index value defining HSV-2 positivity from >1.1 to >or=3.0 either among HSV-1-positive men or among those without a history or clinical evidence of genital lesions increased the PPV to >or=93%. Western blot positivity was more common in men without herpes simplex virus type 1 (HSV-1) antibody than in those with HSV-1 antibody (93 vs 76, P 0.02) and in men with a history or clinical evidence of genital lesions (88 vs 80, P 0.30).
Western blot positivity was more common in men without herpes simplex virus type 1 (HSV-1) antibody than in those with HSV-1 antibody (93% vs 76%, P = 0.02) and in men with a history or clinical evidence of genital lesions (88% vs 80%, P = 0.30). Ninety-one (84%) of 108 HSV-2 ELISA-positive sera tested HSV-2 Western blot-positive. HSV-2 Western blots were then prospectively performed on sequential sera with indeterminate HSV-2 ELISAs. HSV-2 Western blots were performed on sera from male sexually transmitted disease clinic patients testing HSV-2 ELISA-positive and used to define a new class of indeterminate HSV-2 ELISA result. A negative/normal test means you are considered herpes negative. This means that about 19 of people who test negative are actually herpes positive. But there is a 19 chance of a false-positive result. PCR testing of blood, serum, or plasma samples is clinically useful only in potential cases of disseminated HSV infection (neonates, immunosuppressed individuals) and not as an aid in the diagnosis of. Value is not indicative of the amount of antibody present in the patient sample. A positive/abnormal test means you are most likely herpes positive. This test is intended for use as an aid in the diagnosis of herpes simplex virus (HSV) infections it also differentiates HSV-1 from HSV-2. The objective of this study was to define the positive predictive value (PPV) of the Focus herpes simplex virus type 2 (HSV-2) enzyme-linked immunosorbent assay (ELISA) in a low HSV-2 prevalence population and to develop a new test interpretation algorithm. Herpes Simplex Virus (HSV), Types 1/2, IgM, By EIA 164806 IgM levels can provide useful information about an acute event. Labcorp test details for Herpes Simplex Virus (HSV) Type 1-Specific.
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